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miR-205 mimic can interact with miR-221 antagomiR via Hoogsteen interactions to form RNAi triple helices. These interact with polyamidoamine (PAMAM) dendrimers to form nanoparticles that can be further crosslinked into a hydrogel by addition of dextran aldehyde. Reproduced with permission.142 Copyright 2015, Nature Publishing Group.
