Table 3.
Adverse events by grade with any relationship to triapine-cisplatin (n = 25).*
| Grade | |||||
|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | |
| Toxicity | No. | No. | No. | No. | No. |
| Allergy/Immunology | 0 | 0 | 1 | 0 | 0 |
| Blood/Bone marrow (other) | 4 | 1 | 2 | 0 | 0 |
| Anemia | 2 | 11 | 4 | 0 | 0 |
| Febrile neutropenia | 0 | 0 | 0 | 0 | 0 |
| Leukopenia | 1 | 0 | 6 | 14 | 0 |
| Thrombocytopenia | 2 | 4 | 6 | 3 | 0 |
| Cardiovascular | 17 | 4 | 11 | 0 | 0 |
| Constitutional (body as a whole) | 31 | 20 | 10 | 1 | 0 |
| Fatigue | 4 | 8 | 11 | 1 | 0 |
| Dermatology/Skin | 9 | 5 | 0 | 0 | 0 |
| Endocrine/Special Senses | 4 | 8 | 0 | 0 | 0 |
| Tinnitus | 2 | 1 | 0 | 0 | 0 |
| Hearing Loss | 2 | 2 | 0 | 0 | 0 |
| Gastrointestinal (general) | 26 | 11 | 5 | 0 | 0 |
| Constipation | 7 | 3 | 1 | 0 | 0 |
| Diarrhea | 4 | 1 | 2 | 0 | 0 |
| Dysphagia | 0 | 1 | 0 | 1 | 0 |
| Emesis | 3 | 5 | 2 | 0 | 0 |
| Nausea | 5 | 4 | 6 | 0 | 0 |
| Infection | 0 | 2 | 1 | 1 | 0 |
| Metabolic/Nutritional | 29 | 37 | 11 | 2 | 0 |
| Creatinine increased | 4 | 1 | 0 | 0 | 0 |
| Hypokalemia | 4 | 0 | 3 | 0 | 0 |
| Hyponatremia | 3 | 0 | 3 | 1 | 0 |
| Musculoskeletal | 4 | 6 | 0 | 0 | 0 |
| Neurology | 27 | 13 | 4 | 0 | 0 |
| Respiratory System | 22 | 9 | 4 | 1 | 0 |
| Dyspnea | 3 | 2 | 6 | 0 | 0 |
| Hypoxia | 1 | 0 | 1 | 0 | 0 |
| Renal/genitourinary | 2 | 2 | 3 | 0 | 0 |
| Sexual/reproductive function | 0 | 0 | 0 | 0 | 0 |
| Worst non-hematologic | 213 | 145 | 85 | 8 | 0 |
| Worst hematologic | 9 | 16 | 18 | 17 | 0 |
*
Patients may have had more than one adverse event.
Abbreviations: No. = number