Table 4.
Correlations between changes in serum cytokine concentrations and changes in indices of glucoregulation.
| Pearson correlation coefficient (P value) | ||||
|---|---|---|---|---|
| ISI (Matsuda & DeFronzo index) | ISI (Stumvoll index) | OGTT Glucose AUC | OGTT Insulin AUC | |
| Leptin, pg/mL | −0.52 (<0.0001) | 0.06 (0.69) | 0.08 (0.56) | −0.02 (0.86) |
| Total adiponectin, μg/mL | −0.27 (0.06) | −0.01 (0.94) | 0.18 (0.20) | −0.09 (0.51) |
| HMW adiponectin, μ/mL | −0.50 (0.0002) | −0.04 (0.80) | 0.11 (0.43) | 0.14 (0.31) |
| Adiponectin ratio (HMW:total) | −0.25 (0.08) | 0.03 (0.82) | −0.11 (0.43) | 0.16 (0.27) |
| MCP-1, pg/mL | −0.20 (0.16) | 0.00 (0.99) | 0.09 (0.52) | −0.03 (0.84) |
| Pentraxin 3, ng/mL | 0.53 (<0.0001) | −0.08 (0.57) | −0.15 (0.28) | −0.24 (0.09) |
| C-reactive protein, mg/L | 0.01 (0.94) | 0.17 (0.22) | −0.11 (0.43) | −0.24 (0.09) |
| sTNFR1, ng/mL | 0.08 (0.58) | −0.08 (0.56) | 0.12 (0.40) | −0.12 (0.39) |
| GLP-1 AUC, pmol/L·min | −0.21 (0.14) | 0.001 (0.99) | 0.009 (0.95) | 0.09 (0.50) |
| GIP AUC, pmol/L·min | −0.54 (<0.0001) | −0.24 (0.08) | 0.47 (0.0004) | 0.45 (0.0009) |
| DPP-IV, ng/mL | −0.07 (0.63) | 0.03 (0.84) | 0.04 (0.78) | 0.08 (0.58) |
Values are Pearson correlation coefficients, with p-values in parentheses. Bold font indicates significant correlations based on P≤0.05. Analyses were performed on transformed data (log or power transformations, as appropriate for each variable) to normalize data distributions.