Table 5.

Multiple regression analysis to evaluate changes in serum cytokine concentrations as determinants of the changes in insulin sensitivity resulting from weight loss.

Variable	Entry into model	Coefficient	SE	P-value	R2
Full model	----	----	----	<0.0001	0.63
Intercept	----	−0.373	0.39	0.34	----
Pentraxin-3 change, ng/mL	1st	2.776	1.067	0.01	0.28
Leptin change, pg/mL	2nd	−0.023	0.006	0.001	0.17
GIP AUC, pmol/L·min	3rd	−0.001	0.0003	0.0002	0.14
HMW adiponectin change, μ/mL	4th	−2.404	1.132	0.039	0.04

Regression analysis was performed using a forward selection approach, only including cytokines that were significant predictors of changes in insulin sensitivity, based on bivariate correlations as shown in Table 4. Analyses were performed on transformed data (log or power transformations, as appropriate for each variable) to normalize data distributions.