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. Author manuscript; available in PMC: 2018 Jan 11.
Published in final edited form as: J Am Chem Soc. 2016 Dec 27;139(1):255–261. doi: 10.1021/jacs.6b10274

Figure 4.

Figure 4

DNA fragments formed upon reaction with the natural product bleomycin, shown starting with the C4′ radical intermediate and with excision of most atoms of a guanosine (G) nucleoside.14 Carbon atoms C1′-C5′ are marked on each structure. The 3′-phosphoglycolate, 5′-phosphate, and base propenal products are shown. The 3′-phosphoglycolate is a carboxylic acid and therefore capturable by the selection strategy of Figure 1.