Table 2.

Recommendations

1. Policymakers should not attempt to restrict scientific inquiry solely because there are divergent moral views among interested parties.

2. Restrictive policies should be targeted to those dimensions of the research or its applications that have been determined to be unacceptable and should be proportionate to the magnitude of what is morally at stake.

3. Specific consent need not be required of tissue donors for the use of their tissues to derive gametes that are intended for in vitro use only, without the production of embryos.

4. Prior to reproductive uses of these cells commencing, appropriate oversight structures must be in place.

5. There should be requirements for specific consent by tissue donors for use of their tissues to derive gametes that are intended for use in reproduction. This is meant to include those whose skin or other somatic tissues are manipulated to become gametes through iPSC technology. This would also rule out the use of tissue from fetuses, minors, and the deceased for these purposes.

6. Early attempts should take place only within the context of carefully conducted clinical research that conforms to the highest ethical standards.

7. The health and well-being of female participants and their developing fetuses should be monitored carefully. Pregnancy outcomes should be recorded. The health and well-being of children born should be monitored in long-term follow-up studies.