Table 4.

Prevalence of amino acids at positions 37, 41, and 55 in matched brain and spleen Vpr sequences collected using deep sequencing. Matched samples from three HIV-1-infected patients were sequenced using NGS focused on vpr in genomic DNA. The prevalence of each amino acid at a site is shown as a fraction of the total. Bold text highlights the niVpr variants (Fig. 2). Abbreviations: HOC, head of caudate; SPL, spleen.

Patient	Region	A37	I37	L37	M37	P37	T37	V37	D41	G41	N41	S41	A55	55-T
T56766	HOC		1.00								1.00
T56766	SPL	0.11	0.12	0.12		0.02	0.02	0.61		1.00			1.00
T86883	HOC		1.00						0.17	0.33	0.17	0.33	0.60	0.40
T86883	SPL					1.00				1.00			1.00
T96768	HOC					1.00						1.00		1.00
T96768	SPL		0.08	0.22	0.02	0.49	0.20			0.26		0.74	0.32	0.68