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. 2017 Jan 12;7:530. doi: 10.3389/fphar.2016.00530

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Copyright © 2017 Perazzo, Castanho and Sá Santos.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Phosphorylated-tau (p-Tau) levels dependence on KTP concentration both in AD (red) and normal group (white). (A) Complete data set with individual values (linear regression line plotted as a guide to the eye). (B) The data set presented in (A) was clustered in classes according to regular intervals of amplitude of 100 pg/mL of p-tau concentration and averaged for KTP concentration (error bars: standard error). The average KTP value of all classes was compared to control (^∗p < 0.04, ^∗∗p < 0.0075, ^∗∗∗p < 0.0006) or the 100- to 200-pg/mL p-tau class (^#p < 0.04, ^##p < 0.0046) using the one-way ANOVA with Dunnett’s post-test (Santos et al., 2013).