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. 2017 Jan 12;9:168. doi: 10.3389/fnmol.2016.00168

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Copyright © 2017 Parker, Welch, Forster, Tasneem, Dubhashi and Baro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of HCN2 channels SUMOylation sites. Amino acid sequences for the vertebrate and invertebrate HCN channels were aligned: mouse HCN1 (NP_034538), mouse HCN2 (NP_032252), mouse HCN3 (NP_032253), mouse HCN4 (NP_001074661), spiny lobster HCN (ABI94038). Putative SUMOylation sites predicted by SUMOplot freeware are indicated in blue (not mutated this study) or red (mutated in this study). The six transmembrane domains (yellow) and CNBD (blue) have been highlighted.