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. 2017 Jan 12;7:667. doi: 10.3389/fimmu.2016.00667

Figure 2.

Figure 2

T cell phenotype is altered by calorie-restricted (CR) and age. Characterization of murine splenic T cells in control (shaded boxes) and CR mice (open boxes) at 6 months (6 MO), 12 months (12 MO), and 22 months (22 MO) of age in C57BL/6J and DBA/2J mice. Significant differences between strains are shown in parentheses. T cells were gated as CD3+ NKp46− (for gating, see Figure S3B in Supplementary Material). Plots represent the percentage of all T cells expressing (A) KLRG1 (22 MO C*), (B) TRAIL and (C) CXCR3 (6 MO CR*; 22 MO C*), and (D) the median fluorescence intensity of CD127 expression by T cells. Horizontal bars represent median values, boxes extend from the 25th to the 75th percentile, and whiskers represent the min to max range. p Values are derived from non-parametric Mann Whitney U tests. ****p ≤ 0.0001, ***p < 0.001, **p < 0.01, and *p < 0.05. Numbers of mice per group ranged from 10 to 13.