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. 2017 Jan 12;7:667. doi: 10.3389/fimmu.2016.00667

Figure 5.

Figure 5

Natural killer (NK) cell maturation is delayed in calorie-restricted (CR) mice. Maturation phenotype of murine splenic NK cells in control (shaded boxes) and CR mice (open boxes) at 6 months (6 MO), 12 months (12 MO), and 22 months (22 MO) of age in C57BL/6J and DBA/2J mice. (A) Gating and definition of CD27/CD11b defined NK cell subsets, (B) percentage of NK cells in each CD11b/CD27 defined subset; the numbers below the x-axis refer to the NK cell subsets as defined in (A), (C) ratio of S2:S4 NK cell subsets; significant differences between strains were observed for 6 MO CR** and 12 MO C* mice. Horizontal bars represent median values, boxes extend from the 25th to the 75th percentile, and whiskers represent the min to max range. p Values are derived from non-parametric Mann Whitney U tests. ****p ≤ 0.0001, ***p < 0.001, **p < 0.01, and *p < 0.05. Numbers of mice per group ranged from 10 to 13.