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. 2017 Jan 12;7:667. doi: 10.3389/fimmu.2016.00667

Figure 6.

Figure 6

Natural killer (NK) cell maturation status only partially explains altered NK cell phenotype in C57BL/6 calorie-restricted (CR) mice. Characterization of C57BL/6 splenic NK cells by maturation status (numbered 1 through 4 below the x-axis, as defined in Figure 5A) in control (shaded boxes) and CR mice (open boxes) at 6 months (6 MO), 12 months (12 MO), and 22 months (22 MO) of age. (A–G) Plots represent the percentage of NK cells (NKp46+, CD3−) in each CD27/CD11b defined subset expressing (A) CD127, (B) CD25, (C) TRAIL, (D) CXCR3, (E) CD218a, (F) KLRG1, and (G) NKG2A/C/E. For gating, see Figure S4 in Supplementary Material. Horizontal bars represent median values, boxes extend from the 25th to the 75th percentile, and whiskers represent the min to max range. p Values are derived from non-parametric Mann Whitney U tests. ****p ≤ 0.0001, ***p < 0.001, **p < 0.01, and *p < 0.05. Numbers of mice per group ranged from 10 to 13.