Table 1.
Data on women (n = 5615) and men (n = 6600) aged 45+ years with a diagnosis of atrial fibrillation and without (n = 12,121) or with (n = 162) a hemorrhagic stroke (HS) in primary care from January 1, 2001, to December 31, 2007
| Women | Men | |||||
|---|---|---|---|---|---|---|
| Without HS | With HS | Without HS | With HS | |||
| n = 5548 | n = 67 | p value | n = 6505 | n = 95 | p value | |
| Age (years), mean (SD) | 77.1 (9.3) | 77.3 (7.2) | 0.80 | 72.1 (10.2) | 75.2 (9.0) | 0.0032 |
| Age group (years) | 0.28 | 0.067 | ||||
| n (%) | n (%) | n (%) | n (%) | |||
| 45–54 | 104 (1.9) | 0 (0.0) | 368 (5.7) | 1 (1.1) | ||
| 55–64 | 516 (9.3) | 4 (6.0) | 1205 (18.5) | 12 (12.6) | ||
| 65–74 | 1246 (22.5) | 16 (23.9) | 1994 (30.7) | 32 (33.7) | ||
| 75–84 | 2488 (44.8) | 37 (55.2) | 2287 (35.2) | 35 (36.8) | ||
| 85+ | 1194 (21.5) | 10 (14.9) | 651 (10.0) | 15 (15.8) | ||
| Neighborhood SES | 0.13 | 0.25 | ||||
| High | 1921 (34.6) | 16 (23.9) | 2597 (39.9) | 41 (43.2) | ||
| Middle | 2734 (49.3) | 36 (53.7) | 2966 (45.6) | 46 (48.4) | ||
| Low | 893 (16.1) | 15 (22.4) | 942 (14.5) | 8 (8.4) | ||
| Marital status | 0.41 | 0.40 | ||||
| Married | 1643 (29.8) | 14 (20.9) | 3865 (59.7) | 62 (65.3) | ||
| Unmarried | 391 (7.1) | 6 (9.0) | 617 (9.5) | 8 (8.4) | ||
| Divorced | 780 (14.1) | 12 (17.9) | 1002 (15.5) | 9 (9.5) | ||
| Widowed | 2708 (49.0) | 35 (52.2) | 996 (15.4) | 16 (16.8) | ||
| Educational level | 0.48 | 0.58 | ||||
| Compulsory school | 2561 (52.6) | 29 (48.3) | 2433 (39.5) | 34 (39.5) | ||
| Secondary school | 1598 (32.8) | 24 (40.0) | 2318 (37.6) | 36 (41.9) | ||
| College/university | 712 (14.6) | 7 (11.7) | 1410 (22.9) | 16 (18.6) | ||
| AF-related disease | ||||||
| Hypertension | 2706 (48.8) | 39 (58.2) | 0.13 | 2694 (41.4) | 39 (41.1) | 0.58 |
| CHD | 1156 (20.8) | 15 (22.4) | 0.76 | 1314 (20.2) | 18 (19.0) | 0.76 |
| Heart failure | 1140 (20.6) | 8 (11.9) | 0.082 | 1127 (17.3) | 22 (23.2) | 0.14 |
| Valvular disease | 272 (4.9) | 4 (6.0) | 0.57 | 288 (4.4) | 3 (3.2) | 0.80 |
| Diabetes mellitus | 1076 (19.4) | 12 (17.9) | 0.76 | 1284 (19.7) | 16 (16.8) | 0.48 |
| Drugs | ||||||
| Ever warfarin | 2651 (47.8) | 38 (56.7) | 0.15 | 3651 (56.1) | 57 (60.0) | 0.45 |
| Warfarin ITT | 2568 (46.3) | 38 (56.7) | 0.089 | 3541 (54.4) | 57 (60.0) | 0.28 |
| Warfarin PP | 2015 (36.3) | 23 (34.3) | 0.74 | 2763 (42.5) | 42 (44.2) | 0.73 |
| Ever ASA | 3242 (58.4) | 36 (53.7) | 0.44 | 3416 (52.5) | 53 (55.8) | 0.53 |
| ASA ITT | 2863 (51.6) | 31 (46.3) | 0.39 | 3007 (46.2) | 45 (47.4) | 0.83 |
| ASA PP | 1780 (32.1) | 16 (23.9) | 0.15 | 1924 (29.6) | 25 (26.3) | 0.49 |
| Ever clopidogrel | 195 (3.5) | 0 | 0.17 | 202 (3.1) | 3 (3.2) | 0.77 |
| Clopidogrel ITT | 141 (2.5) | 0 | 0.42 | 159 (2.4) | 3 (3.2) | 0.51 |
| Clopidogrel PP | 61 (1.1) | 0 | 1.0 | 61 (0.9) | 1 (1.1) | 0.60 |
Prescription of antithrombotic drug was classified as “intention to treat” (ITT) if ever present before the year of the first stroke or present among subjects not experiencing a stroke and classified as “per protocol” (PP) if present the year before and the year of first stroke or present among subjects not experiencing a stroke if present at least during 3 years, of at least 50 % of actual years after the first recorded year of AF or during both 2006 and 2007