Table 1.

Association of genome-wide significant loci for intracranial volume in European, African, Asian, and Hispanic populations.

						European discovery (N=26,577)		European replication (N=2,363)		African generalization (N=938)		Asian generalization (N=955)		Hispanic generalization (N=1605)
Genetic variant	Locus	Position	A1	A2	Freq	β	P	β	P	β	P	β	P	β	P
rs199525	17q21	44847834	T	G	0.80	.102	3.8×10−21	.024	0.407	.358	1.3×10−3	.264	0.406	.035	0.493
rs11759026	6q22	126792095	A	G	0.76	−.095	2.2×10−20	−.019	0.528	−.131	0.194	−.071	0.123	−.046	0.209
rs2022464	6q21	108945370	A	C	0.30	−.063	3.7×10−11	−.090	4.7×10−3	−.060	0.233	−.105	0.035	−.088	0.013
rs11191683	10q24	105170649	T	G	0.33	.059	1.1×10−10	.040	0.174	.187	0.021	.085	0.075	−.005	0.911
rs9811910	3q28	190670902	C	G	0.08	.096	1.2×10−9	.075	0.010	.346	0.020	.101	0.621	−.148	0.187
rs138074335	12q14	66374247	A	G	0.59	.051	6.2×10−9	.106	2.9×10−4	−.016	0.735	−.004	0.951	.001	0.984
rs2195243	12q23	102922986	C	G	0.22	−.059	1.5×10−8	−.044	0.132	.037	0.585	−.020	0.774	−.093	0.101

Abbreviations: A1 = effect allele, A2 = reference allele, Freq = frequency of the effect allele, SE = standard error, N = sample size.