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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Nat Neurosci. 2016 Oct 3;19(12):1569–1582. doi: 10.1038/nn.4398

Table 2.

Genetic correlation between intracranial volume and other anthropometric traits, cognitive function, and neurodegenerative diseases.

Intracranial volume
Full sample (N=26,577)		 Intracranial volume
Height subset (N=22,378)		 Intracranial volume
Height adjusted (N=21,875)
Phenotype N total N cases Mean χ2 ρgenetic SE P ρgenetic SE P ρgenetic SE P
Anthropometric traits
    Adult height 253,280 - 2.98 .249 .037 1.4×10−11 .241 .038 2.4×10−10 .049 .039 0.21
    Child head circumference 10,768 - 1.04 .748 .121 5.5×10−10 .758 .124 1.1×10−9 .750 .126 2.5×10−9
    Birth length 28,459 - 1.07 .296 .087 6.7×10−4 .278 .087 1.3×10−3 .192 .088 0.029
    Birth weight 26,836 - 1.06 .285 .081 4.4×10−4 .219 .082 7.9×10−3 .160 .086 0.062
Neurological traits
    Childhood cognitive function 12,441 - 1.08 .277 .090 2.2×10−3 .277 .091 2.5×10−3 .257 .090 4.2×10−3
    Adult cognitive function 53,949 - 1.15 .202 .059 6.3×10−4 .205 .060 6.0×10−4 .198 .059 6.9×10−4
    Alzheimer’s Disease 54,162 17,008 1.11 −.070 .097 0.47 −.049 .097 0.61 −.043 .098 0.66
    Parkinson’s Disease 108,990 13,708 1.10 .315 .063 6.6×10−7 .316 .070 5.5×10−6 .335 .072 3.0×10−6
    White matter lesions 17,936 - 1.07 .112 .075 0.13 .111 .078 0.16 .096 .079 0.23
Psychiatric traits
    Autism 10,263 4,949 1.07 −.011 .069 0.87 −.036 .074 0.63 .026 .071 0.72
    Bipolar disorder 11,810 6,990 1.14 .070 .071 0.33 .007 .075 0.93 −.004 .076 0.95
    Major depressive disorder 16,610 9,227 1.07 .002 .100 0.98 .025 .098 0.80 .005 .096 0.96
    Schizophrenia 17,115 9,379 1.23 .054 .056 0.33 .017 .058 0.77 −.009 .058 0.87
    Extraversion 63,030 - 1.08 −.041 .092 0.65 −.101 .095 0.29 −.097 .092 0.29
    Neuroticism 63,661 - 1.06 −.017 .109 0.87 .035 .106 0.74 .070 .111 0.53

Genetic correlation between various phenotypes and intracranial volume in the complete discovery sample (“Full sample”), adjusted for height in the studies that had measured height (“Height adjusted”), and the corresponding subset of studies without adjustment (“Height subset”).

Abbreviations: SE = standard error.

Genetic correlation between various phenotypes and intracranial volume in the complete discovery sample (“Full sample”), adjusted for height in the studies that had measured height (“Height adjusted”), and the corresponding subset of studies without adjustment (“Height subset”).

Abbreviations: SE = standard error.