Table 2.

Genotype analysis of polymorphisms in growth hormone receptor (GHR ) gene between overweight/obesity and control subjects

SNPs	Genotype	Control	Overweight/obese	Models	OR (95% CI)	P-value
rs6451620 intron	G/G	52 (33.5)	82 (38.9)	Dominant	0.77 (0.49–1.20)	0.24
	A/G	76 (49.0)	102 (48.3)	Recessive	0.68 (0.38–1.23)	0.21
	A/A	27 (17.4)	27 (12.8)	Log-additive	0.79 (0.58–1.08)	0.14
rs4130114 intron	T/T	128 (83.7)	179 (87.3)	Dominant	0.77 (0.42–1.40)	0.39
	G/T	24 (15.7)	26 (12.7)	Recessive	0.00 (0.00–NA)	NA
	G/G	1 (0.6)	0 (0)	Log-additive	0.75 (0.42–1.35)	0.33
rs4410646 intron	A/A	71 (45.2)	68 (32.2)	Dominant	1.68 (1.09–2.60)	0.02*
	A/C	63 (40.1)	103 (48.8)	Recessive	1.31 (0.74–2.32)	0.35
	C/C	23 (14.7)	40 (19.0)	Log-additive	1.38 (1.02–1.87)	0.036*
rs6898743 intron	C/C	52 (33.1)	96 (45.7)	Dominant	0.63 (0.41–0.98)	0.039*
	C/G	77 (49.0)	86 (41.0)	Recessive	0.71 (0.40–1.28)	0.26
	G/G	28 (17.8)	28 (13.3)	Log-additive	0.73 (0.54–0.99)	0.044*
rs4394131 intron	T/T	127 (81.4)	170 (81.0)	Dominant	1.06 (0.62–1.83)	0.82
	A/T	28 (17.9)	38 (18.1)	Recessive	1.51 (0.13–17.25)	0.73
	A/A	1 (0.6)	2 (1.0)	Log-additive	1.08 (0.65–1.78)	0.78
rs6182 Cys440Phe	G/G	134 (85.3)	187 (89.0)	Dominant	0.70 (0.37–1.31)	0.26
	G/T	22 (14.0)	23 (10.9)	Recessive	0.00 (0.00–NA)	0.13
	T/T	1 (0.6)	0 (0)	Log-additive	0.67 (0.37–1.23)	0.20
rs6184 Pro579Thr	C/C	133 (85.3)	179 (88.6)	Dominant	0.74 (0.39–1.39)	0.35
	A/C	23 (14.7)	23 (11.4)	Recessive	NA	NA
	A/A	0 (0)	0 (0)	Log-additive	NA	NA

Values are presented as number (%).

SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence interval; NA, not applicable.

^*P<0.05 significant association.