Table 3.
Allele analysis of polymorphisms in growth hormone receptor (GHR ) gene between overweight/obesity and control subjects
| SNPs | Allele | Control | Overweight/obese | OR (95% CI) | P-value |
|---|---|---|---|---|---|
| rs6451620 intron | G | 180 (58.1) | 266 (63.0) | 1 | |
| A | 130 (41.9) | 156 (37.0) | 0.812 (0.602–1.096) | 0.17 | |
|
| |||||
| rs4130114 intron | T | 280 (91.5) | 384 (93.7) | 1 | |
| G | 26 (8.5) | 26 (6.3) | 0.729 (0.414–1.283) | 0.27 | |
|
| |||||
| rs4410646 intron | A | 205 (65.3) | 239 (56.6) | 1 | |
| C | 109 (34.7) | 183 (43.4) | 1.440 (1.065–1.947) | 0.018* | |
|
| |||||
| rs6898743 intron | C | 181 (57.6) | 278 (66.2) | 1 | |
| G | 133 (42.4) | 142 ( 33.8) | 0.695 (0.514–0.940) | 0.018* | |
|
| |||||
| rs4394131 intron | T | 282 (90.4) | 378 (90.0) | 1 | |
| A | 30 (9.6) | 42 (10.0) | 1.044 (0.638–1.710) | 0.86 | |
|
| |||||
| rs6182 Cys440Phe | G | 290 (92.4) | 397 (94.5) | 1 | |
| T | 24 (7.6) | 23 (5.5) | 0.700 (0.387–1.265) | 0.24 | |
|
| |||||
| rs6184 Pro579Thr | C | 289 (92.6) | 381 (94.3) | 1 | |
| A | 23 (7.4) | 23 (5.7) | 0.759 (0.417–1.379) | 0.37 | |
Values are presented as number (%).
SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence interval; NA, not applicable.
*
P<0.05 significant association.