Table 2. Identified QTSs for cholesterol using full model approach.
Chr_SNP_Alleles | Gene | Effect | Estimate | SE | −log10PEW | h2 (%) |
---|---|---|---|---|---|---|
1_rs629301_T/G | CELSR2 | a | 4.94 | 0.40 | 34.47 | 1.46 |
2_rs478442_A/C | 132 kb 5′ of APOB | a | 5.73 | 0.39 | 47.61 | 1.97 |
de1 | −3.85 | 0.85 | 5.23 | 1.32 | ||
de4 | 5.40 | 1.26 | 4.75 | |||
4_rs7694118_C/T | 1.8 kb 5′ of PCDH10 | d | 3.11 | 0.64 | 6.01 | 0.58 |
de1 | 8.31 | 2.12 | 5.04 | 3.18 | ||
de3 | −6.08 | 0.96 | 9.60 | |||
5_rs17409624_G/A | DROSHA | a | 2.14 | 0.45 | 5.70 | 0.27 |
7_rs6465748_G/A | 9.6 kb 5′ of MYH16 | a | −3.11 | 0.35 | 18.43 | 0.58 |
ae3 | −4.67 | 0.68 | 11.12 | 1.22 | ||
ae4 | 4.33 | 0.71 | 9.04 | |||
8_rs10503377_C/T | 139 kb 5′ of SGK223 | a | 3.16 | 0.42 | 13.50 | 0.60 |
11_rs10768634_T/C | OR52A1 | d | −3.45 | 0.64 | 7.19 | 0.71 |
11_rs7124873_G/A | 10 kb 3′ of MMP13 | a | 2.57 | 0.44 | 8.13 | 0.40 |
14_rs10483461_C/T | 117 kb 3′ of BRMS1L | a | 2.35 | 0.34 | 11.05 | 0.33 |
ae3 | 4.02 | 0.69 | 8.17 | 0.97 | ||
15_rs12595211_G/A | ETFA | a | −2.52 | 0.42 | 8.51 | 0.38 |
16_rs1532625_G/A | CETP | a | −2.85 | 0.43 | 10.46 | 0.49 |
17_rs2649485_C/T | 3.3 kb 5′ of CCDC144B | a | −2.58 | 0.45 | 8.12 | 0.40 |
19_rs1654452_C/T | RDH13 | a | −2.02 | 0.43 | 5.64 | 0.25 |
2_rs478442_A/C × | 132 kb 5′ of APOB × | aa | 2.38 | 0.46 | 6.77 | 0.34 |
4_rs7694118_C/T | 1.8 kb 5′ of PCDH10 | da | 3.59 | 0.67 | 7.09 | 0.77 |
7_rs2264802_C/A × | SKAP2 × UFM1 | aa | −4.71 | 0.44 | 26.41 | 1.33 |
13_rs9548318_G/A | ad | −6.14 | 0.86 | 12.16 | 2.26 | |
10_rs12246594_A/T × | SORCS1 × ETFA | aa | 7.46 | 0.44 | 13.34 | 3.34 |
15_rs12595211_G/A |
Chr_SNP_Alleles: chromosome_SNP_major/minor alleles; Gene: the near or holder genes corresponding to QTSs; Effect: genetic effects of QTSs, a = additive effect, d = dominance effect, aa = additive-additive epistasis effect, ad = additive-dominance epistasis effect, da = dominance-additive epistasis effect, ae3 = A-A specific additive effect, ae4 = H-A specific additive effect, de1 = E-A specific dominance effect, de3 = A-A specific dominance effect, de4 = H-A specific dominance effect; Estimate: the estimated genetic effects; −log10PEW: minus log10 (experimental-wise P-value); h2 (%) refers heritability in percentage.