Table 1. Offline evaluation of integrated hybrid cryogel based bioreactor seeded with HepG2 cells.
| Bilirubin |
AST |
Ammonia |
Albumin |
Urea |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UT | T | % change | UT | T | % change | UT | T | % change | UT | T | % change | UT | T | % change | |
| P1 | 15.09 | 3.86 | −74.42 | 341.2 | 105.9 | −68.96 | 290.3 | 189.5 | −34.72 | 2.38 | 3.59 | +50.84 | 7.12 | 12.66 | +77.81 |
| P2 | 12.51 | 3.37 | −73.06 | 201.6 | 105.3 | −47.77 | 266.1 | 163.9 | −38.41 | 1.68 | 3.36 | +100 | 9.59 | 12.66 | +32.01 |
| P3 | 3.91 | 0.99 | −74.68 | 68.95 | 58.34 | −15.39 | 276.2 | 162.3 | −41.24 | 2.01 | 3.13 | +55.72 | 12.33 | 12.81 | +3.89 |
| P4 | 8.04 | 3.12 | −61.19 | 208.6 | 85.3 | −59.11 | 282.6 | 166.3 | −41.15 | 2.22 | 3.74 | +68.47 | 9.86 | 12.81 | +29.9 |
| P5 | 6.84 | 1.99 | −70.91 | 118.5 | 107.4 | −9.37 | 289.5 | 200.7 | −30.67 | 1.76 | 3.31 | +88.07 | 10.55 | 10.45 | −0.95 |
| P6 | 3.9 | 1.09 | −72.05 | 150.3 | 82.2 | −45.31 | 293.3 | 164.4 | −43.95 | 1.75 | 3.61 | +31.27 | 7.31 | 9.63 | +31.74 |
| P7 | 3.3 | 1.33 | −59.7 | 178.6 | 102.3 | −42.72 | 263.9 | 146.3 | −44.56 | 2.04 | 3.42 | +67.65 | 12.33 | 12.35 | +0.162 |
| P8 | 3.85 | 1.05 | −72.72 | 111.4 | 80 | −28.19 | 272.4 | 153.1 | −43.8 | 1.94 | 3.16 | +62.89 | 7.81 | 9.5 | +21.64 |
| P9 | 5.27 | 1.34 | −74.57 | 106.1 | 84.2 | −20.64 | 275.2 | 165.2 | 39.97 | 1.51 | 3.03 | +20.72 | 7.31 | 9.62 | +31.6 |
| Avg | −70.4 ± 5.8 | −37.5 ± 20 | −39.8 ± 4.6 | +60.6 ± 25 | +25.3 ± 24 | ||||||||||
| Ref | 0.3–1.2 mg/dL | 10–40 IU/L | 12–60 μg/dL | 3.5–5.2 g/dL | 15–40 mg/dL | ||||||||||
UT: Untreated patient plasma; T: Treated patient plasma. Percent change in parameter post-treatment calculated as the difference between T and UT divided by UT multiplied by 100 (i.e ((T-UT)/UT)*100). Positive (negative) sign represents an increase (decrease). Average (Avg) is the mean ± SD (n = 9) value of percent increase or decrease obtained from 9 samples treated in the integrated bioreactor. Reference (Ref) is the normal human plasma values for the biochemical parameters in the table.