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(A) Locally advanced giant cell tumor of the humerus bone on anterior-posterior X-ray view prior to denosumab treatment. (B) The same tumor on lateral X-ray view prior to denosumab treatment. (C) Response on X-ray to denosumab therapy after 7 months of treatment. (D) X-ray after en bloc resection and prosthetic replacement reconstruction following denosumab therapy.
