Table II.
Associations between clinicopathological factors and PDIA3 expression in hepatocellular carcinoma.
| PDIA3 expression | ||||
|---|---|---|---|---|
| Characteristic | n | High (n=56) | Low (n=30) | P-value |
| Gender | 0.819 | |||
| Male | 51 | 34 | 17 | |
| Female | 35 | 22 | 13 | |
| Age, years | 0.482 | |||
| <65 | 31 | 22 | 9 | |
| ≥65 | 55 | 34 | 21 | |
| HBsAg | 0.806 | |||
| Positive | 26 | 16 | 10 | |
| Negative | 60 | 40 | 20 | |
| HCV | 0.819 | |||
| Positive | 51 | 34 | 17 | |
| Negative | 35 | 22 | 13 | |
| Cirrhosis | 0.251 | |||
| Yes | 51 | 36 | 15 | |
| No | 35 | 20 | 15 | |
| Preoperative AFP, ng/ml | 1 | |||
| <20 | 44 | 29 | 15 | |
| ≥20 | 42 | 27 | 15 | |
| Preoperative DCP, mAU/ml | 0.645 | |||
| <40 | 32 | 22 | 10 | |
| ≥40 | 54 | 34 | 20 | |
| Tumor size, cm | 0.143 | |||
| <5 | 59 | 35 | 24 | |
| ≥5 | 27 | 21 | 6 | |
| Tumor number | 0.24 | |||
| 1 | 54 | 32 | 20 | |
| <1 | 32 | 24 | 8 | |
| Vascular invasion | 0.815 | |||
| Positive | 31 | 21 | 10 | |
| Negative | 55 | 35 | 20 | |
| UICC stage | 0.287 | |||
| I | 35 | 19 | 16 | |
| II | 44 | 31 | 13 | |
| III | 6 | 5 | 1 | |
| IV | 1 | 1 | 0 | |
| Differentiation | 0.066 | |||
| Well | 17 | 15 | 2 | |
| Moderate | 54 | 31 | 23 | |
| Poor | 15 | 10 | 5 | |
| Local recurrence | 0.503 | |||
| Yes | 47 | 29 | 18 | |
| No | 39 | 27 | 12 | |
| Distal metastasis | 0.66 | |||
| Yes | 6 | 5 | 1 | |
| No | 80 | 51 | 29 | |
HBsAg, hepatitis B surface antigen; HCV, hepatitis C virus; PDIA3, protein disulfide-isomerase A3; AFP, α-fetoprotein; DCP, des-gamma-carboxy prothrombin; UICC, Union for International Cancer Control.