Figure 5.

FGFRL1 acts as a tumor suppressor in vivo. Inducible HEK 293 Tet-On-FGFRL1ΔC cells (clone K13ΔC) were injected into nude mice at two ventral positions. Expression of FGFRL1 was induced in half of the animals by doxycycline, which was added to their drinking water. The other half received normal drinking water. Tumor formation was inspected at the injection sites after 5 weeks. Two representative examples of each group are depicted. The injected cells were able to generate tumors only in those mice that did not receive any doxycycline. FGFRL1, fibroblast growth factor receptor-like 1; Dox, doxycycline.