Figure 2. Effect of the condition modalities (cool, warm, TGI) on cortical responses to noxious heat stimulation (N2P2 and N1 amplitudes).

(A) N2P2 and (B) N1 changes in amplitude during cool, warm, and TGI conditioning (+/−standard error). Only TGI conditioning resulted in facilitation of cortical responses to noxious heat stimulation. Averaged N2P2 and N1 waveforms (C,D), demonstrating facilitation of CHEPs during TGI conditioning.