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. 2016 Oct 13;12(6):4419–4426. doi: 10.3892/ol.2016.5250

Figure 1.

Figure 1.

PTEN was confirmed to be a target gene of miR-221/222. (A) Sequences of miR-221/222, the PTEN 3′UTR and the mutPTEN 3′UTR, including the binding sites of PTEN-miR-221/222. (B) Luciferase activity ratio of PTEN 3′UTR and mutPTEN 3′UTR luciferase constructs when transfected with miR-221/222 mimics, mimics NC, miR-221/222 inhibitor or inhibitor NC (*P<0.05). miR-221, microRNA-221/222; PTEN, phosphatase and tensin homolog; 3′UTR, 3′ untranslated region; mutPTEN, mutated PTEN; NC, negative control.