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Effect of the miR-221/222 sponge on the invasive ability of oral squamous cell carcinoma cells was investigated by Transwell assay. Invasive ability decreased in (A) CAL27 and (B) HSC6 cells when transfected with the miR-221/222 sponge compared with the control group (**P<0.01 vs. control). Cell counts of invasion (C) CAL27 and (D) HSC cells were observed in 5 random fields (magnification, ×100). miR-221/222, microRNA-221/222.
