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DIOS downregulates Notch3 signaling and inhibits the NF-κB pathway by inactivation of its upstream regulator IKKα/IKKβ. (A) Notch3, cleaved Notch3 and NF-κB were detected by immunoblotting. (B) The p53 cellular location and protein level was analyzed by immunofluorescence (magnification, ×200). (C) IKKα, IKKβ and NF-κB protein level alterations were determined following DIOS stimulation. DIOS, diosmetin; NF, nuclear factor; IKK, IκB kinase.
