Table V.
Histopathological features of liver tissues and grading criteria level in each experimental group.
| Experimental groups | |||
|---|---|---|---|
| Histopathology | Score | Control, n=6 n (%) | Forbesione 50 mg/kg, n=6 n (%) |
| Periportal inflammationa | 0 | 5 (83.3) | 5 (83.3) |
| 1 | 1 (16.7) | 1 (16.7) | |
| 2 | 0 (0.0) | 0 (0.0) | |
| 3 | 0 (0.0) | 0 (0.0) | |
| 4 | 0 (0.0) | 0 (0.0) | |
| Focal inflammationb | 0 | 5 (83.3) | 6 (100.0) |
| 1 | 1 (16.7) | 0 (0.0) | |
| 2 | 0 (0.0) | 0 (0.0) | |
| 3 | 0 (0.0) | 0 (0.0) | |
| 4 | 0 (0.0) | 0 (0.0) | |
a
Periportal or periseptal interface hepatitis (piecemeal necrosis) score: 0, none; 1, mild (focal, few portal areas); 2, mild/moderate (focal, the majority of portal areas); 3, moderate (continuous around <50% of tracts or septa); and 4, severe (continuous around >50% of tracts or septa). P=1.00.
b
Focal inflammation score: 0, none; 1, ≤1 focus/X10 objective; 2, 2–4 foci/X10 objective; 3, 2–4 foci/X10 objective; and 4, 2–4 foci/X10. P=0.182.