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DHA induces expression of JNK downstream genes. (A) RT-PCR analyses of relative Cox-2 mRNA expression in HUVECs treated with DHA and/or SP600125. (B) RT-PCR analyses of relative MMP-13 mRNA expression in HUVECs treated with DHA and/or SP600125. n=4; *P<0.05; **P<0.01. DHA, dihydroartemisinin; RT-PCR, reverse transcription-polymerase chain reaction; Cox-2, cyclooxygenase-2; HUVECs, human umbilical vein endothelial cells; MMP-13, matrix metalloproteinase-13; n.s., non-significant.
