Figure 2.

Hierarchical cluster analysis. Differentially secreted cytokines, which were defined as a >1.5-fold induction from control, were clustered according to their secretion (control or HMGB1-induced). Six HMGB1-induced cytokines (red) and four repressed cytokines (green) were detected. HMGB1, high mobility group box 1; IGFBP, insulin-like growth factor binding protein; CCL-5, chemokine C-C motif ligand 5; MIF, macrophage migration inhibitory factor; EGFR, epidermal growth factor receptor; M-CSF, macrophage colony stimulating factor; VEGF, vascular endothelial growth factor; uPAR, urokinase plasminogen activator receptor; PIGF, placental growth factor.