Table III.
Associations between serum folic acid levels in patients with laryngeal squamous cell carcinoma and clinical stage, histological differentiation and anatomic localization.
| Clinical stage (TNM) | P-value | Histological differentiation and anatomic localization | P-value |
|---|---|---|---|
| I and II | 0.610 | 1 and 2 | 0.110 |
| I and III | 0.002a | 1 and 3 | 0.001b |
| I and IV | 0.001b | 2 and 3 | 0.020a |
| II and III | 0.014a | A and B | 0.001b |
| II and IV | 0.004b | A and C | 0.160 |
| III and IV | 0.320 | B and C | 0.080 |
a
P<0.05
b
P<0.01; 1, well-differentiated; 2, moderately-differentiated; 3, poorly-differentiated; A, supraglottic; B, glottic; C, subglottic; TNM, tumor-node-metastasis.