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Human epidermal growth factor receptor 2/neu oncogene gene status in prostate carcinomas, as detected by chromogenic in situ hybridization. Green signals correspond to HER2, and red signals correspond to (magnification, ×100). (A) HER2 gene non-amplified. (B) HER2 gene amplified. A high level of HER2 gene amplification was detected when the HER2/CEP17 ratio was >2.2. HER2, human epidermal growth factor receptor 2; CEP17, chromosome 17 centromere.
