Figure 1.

Effects of in utero exposure to DEHP on serum (A) leptin and (B) insulin concentrations of F1 offspring. DEHP or vehicle (olive oil) was administered to pregnant females by gavage (0.05 mg/kg) every 24 h from GD1 to 19. F1 offspring were weaned at three weeks of age and fed a standard diet through nine weeks of age. Results are shown as the mean ± standard deviation (n=15 female and 14 male in the F1 control group, n=14 female and 16 male in the F1 DEHP0.05 group). DEHP, di-(2-ethylhexyl) phthalate; GD, gestational day. *P<0.05 vs. the F1 control group.