Figure 3.

Dose effect of chrysin on the viability of uveal melanoma cells, human RPE cells and scleral fibroblasts. Uveal melanoma cells (A) SP6.5, (B) M17, (C) human RPE cells (D) and scleral fibroblasts were seeded into 96-well plates and treated with chrysin at various doses for 48 h, and cell survival was determined by MTT assay. Data are presented as the mean ± standard deviation (percentage of the controls) from three independent experiments, each in triplicate. Chrysin at 30–100 µM levels selectively reduced the viability of uveal melanoma cells, without affecting the viability of uveal melanocytes and fibroblasts. *P<0.05 vs. the control (cells cultured without chrysin). RPE, retinal pigment epithelial.