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. 2016 Nov 11;12(6):3837–3842. doi: 10.3892/etm.2016.3893

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Copyright: © Tang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — miR-218 inhibits the tumor proliferation and angiogenesis in vivo, concomitantly with decreased expression of Ang-2. (A) Tumor growth curve of nude mice xenografted with NCI-87 cells, followed by intratumoral injection of pre-miR-218 or scrambled miRNA, and representative images of the tumors of 3 mice from each group at the end of the experiment. (B) Reverse transcription-quantitative polymerase chain reaction analysis of miR-218 expression levels in tumor tissues. (C) Western blot of the protein expression levels of Ang-2 in tumor tissues. (D) Ang-2 protein levels determined by western blot image analysis. (E) Immunohistochemical staining for tumor vascularization and a graphical representation of the results. Results are presented as the mean ± standard error of the mean of three independent experiments. Scale bar, 50 µm. ***P<0.001. miR, miRNA; Ang-2, angiopoietin-2.