Table I.
Collation of retrospective studies reporting the incidence of concomitant invasive disease or DCIS in the patients with a CNB positive for PLCIS.
| Study | N | Diagnosis on CNB | Surgical procedure | PLCIS alone on surgical specimen | Concurrent DCIS or invasion on surgical specimen | Concurrent DCIS (%) | Concurrent invasive cancer (%) | Ref |
|---|---|---|---|---|---|---|---|---|
| Carder et ala | 10 | PLCIS: 5 | DB: 2 WLE: | 1 | 1 micro ILC, | 0 | 30 | (17) |
| PLCIS | ||||||||
| with microinvasion: 2 | 6 Mx:2 | 2 ILC | ||||||
| PLCIS with CLCIS: 3 | ||||||||
| Chivikula et alb | 12 | PLCIS: 12 | DB: 1 WLE: | 7 | 1 DCIS+ | 8.30 | 25 | (18) |
| 9 Mx: 2 | ILC, 2 ILC | |||||||
| Fasola et al | 34 | PLCIS: 13 | WLE: 20 | 4 | 9 PLCIS+DCIS, | 26.47 | 61.76 | (19) |
| PLCIS ‘with | Mx: 142 | 6 PLCIS+IDC, | ||||||
| invasion’: 21 | 15 PLCIS+ILC | |||||||
| Morris et al | 17 | PLCIS: 3 PLCIS | WLE:17 | 3 | 3 PLCIS+DCIS, | 17.65 | 17.65 | (20) |
| +DCIS: 7 | 11 PLCIS+ILC | |||||||
| PLCIS+IC: 7 | ||||||||
| Niell et al | 5 | PLCIS: 5 | WLE: 5 | 1 | 1 PLCIS+ILC, | 40 | 60 | (21) |
| 1 LCIS+ILC, 1 | ||||||||
| DCIS+IDC, 1 DCIS | ||||||||
| Lavoure et alc | 10 | PLCIS: 10 | WLE: 10 | 7 | 3 PLCIS+ILC | 0 | 30 | (22) |
| Georgian-Smith et al | 5 | PLCIS: 5 | WLE: 5 | 3 | 2 PLCIS+ILC | – | 40 | (23) |
| Mahoney et al | 2 | PLCIS: 2 | WLE: 2 | 1 | 1 PLCIS+ILC | – | 50 | (24) |
| Purdie et ale | 3 | PLCIS: 3 | WLE: 3 | 1 | 1 ILC, 1 PLCIS+ILC | – | 66 | (25) |
| Flanagan et ald | 23 | PLCIS: 23 | WLE: 16 | 12 | 5 ILC, 2 ILC+ | 17 | 30 | (28) |
| Mx: 5 | IDC, 1 DCIS, | |||||||
| 3 PLCIS+DCIS | ||||||||
| Total | 121 | 15.70 | 40.5 |
3 of the 5 PLCIS were initially reported as high grade DCIS.
9 WLE (1 lumpectomy, 8 segmental mastectomies) 2 Mx (1 Simple Mx, 1 Bilateral Mx).
2 of the 7 cases of pure PLCIS were extensive and required Mx.
17 were initially diagnosed by needle biopsy while 6 diagnosed by excisional biopsy. In total 12 of the patients had to undergo Mx.
The PLCIS+ILC was noted as ‘microinvasion’. N, number of patients; CNB, core needle biopsy; PLCIS, pleomorphic carcinoma in situ; CLCIS, classic carcinoma in situ; DCIS, ductal carcinoma in situ; IC, invasive carcinoma; IDC, invasive ductal carcinoma; ILC, invasive lobular carcinoma; DB, diagnostic biopsy; WLE, wide local excision; Mx, mastectomy.