. 2017 Jan 10;5:e2815. doi: 10.7717/peerj.2815

Table 2. Genotype distributions and allele frequencies of CTLA-4 polymorphisms in cases and controls.

Study	Genotype (N)								Allele frequency (N)				P of HWE
	Case				Control				Case		Control
	Total	AA	AB	BB	Total	AA	AB	BB	A	B	A	B
+49A>G (rs231775)
Zhifu et al. (2015)	376	174	175	27	366	174	157	35	523	229	505	227	0.96
Minhas et al. (2014)	250	111	113	26	250	105	121	24	335	165	331	169	0.20
Li et al. (2012)	576	49	281	246	553	54	243	256	379	773	351	755	0.74
Sun et al. (2008)	1,060	101	485	474	1,070	65	446	559	660	1,406	576	1,564	0.15
Sun et al. (2008)	1,037	100	455	482	1,070	73	451	546	655	1,419	597	1,543	0.12
Wang et al. (2007)	117	48	59	10	148	55	70	23	155	79	180	116	0.93
Ghaderi et al. (2004)	197	84	104	9	151	60	72	19	272	122	192	110	0.72
+6230G>A (rs3087243)
Zhifu et al. (2015)	376	257	110	9	366	252	103	11	624	128	607	125	0.90
Li et al. (2012)	581	361	197	23	566	361	182	23	919	243	904	228	0.99
Li et al. (2008)	328	32	124	172	327	20	114	193	188	468	154	500	0.57
Wang et al. (2007)	117	24	47	46	148	18	56	74	95	139	92	204	0.16
−1722T>C (rs733618)
Zhifu et al. (2015)	376	123	186	67	366	137	166	63	432	320	440	292	0.30
Li et al. (2012)	574	184	276	114	551	207	256	88	644	504	670	432	0.55
Li et al. (2008)	328	125	163	40	327	111	168	48	413	243	390	264	0.22
Erfani et al. (2006)	282	225	54	3	245	204	41	0	504	60	449	41	0.15
−1661A>G (rs4553808)
Zhifu et al. (2015)	376	273	91	12	366	281	78	7	637	115	640	92	0.56
Li et al. (2012)	574	405	153	16	551	425	115	11	963	185	965	137	0.33
Kong (2010)	315	204	105	6	322	241	76	5	513	117	558	86	0.72
Wang et al. (2007)	109	62	45	2	148	111	35	2	169	49	257	39	0.68
Erfani et al. (2006)	282	211	65	6	238	184	43	11	487	77	411	65	0.001

Notes.