Table 4. Heterogeneity-analysis results of CTLA-4 polymorphisms and BC risk.
| SNP | B vs. A | BB vs. AA | AB vs. AA | BB vs. AA + AB | AB + BB vs. AA | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| I2 | P | EM | I2 | P | EM | I2 | P | EM | I2 | P | EM | I2 | P | EM | |
| +49A>G (rs231775) | |||||||||||||||
| Overall | 0% | 0.46 | F | 45% | 0.09 | F | 29% | 0.21 | F | 27% | 0.22 | F | 41% | 0.12 | F |
| Chinese | 12% | 0.34 | F | 40% | 0.15 | F | 51% | 0.09 | R | 0% | 0.59 | F | 60% | 0.04 | R |
| PB | 6% | 0.38 | F | 39% | 0.14 | F | 39% | 0.15 | F | 0% | 0.56 | F | 51% | 0.07 | R |
| +6230G>A (rs3087243) | |||||||||||||||
| Chinese | 58% | 0.07 | R | 8% | 0.36 | F | 0% | 0.38 | F | 0% | 0.78 | F | 53% | 0.09 | R |
| PB | 60% | 0.08 | R | 24% | 0.27 | F | 16% | 0.31 | F | 0% | 0.58 | F | 46% | 0.16 | F |
| −1722T>C (rs733618) | |||||||||||||||
| Overall | 52% | 0.10 | R | 51% | 0.10 | R | 7% | 0.36 | F | 35% | 0.22 | F | 39% | 0.18 | F |
| Chinese | 64% | 0.06 | R | 59% | 0.09 | R | 37% | 0.21 | F | 31% | 0.23 | F | 57% | 0.10 | R |
| PB | 0% | 0.74 | F | 0% | 0.45 | F | 0% | 0.99 | F | 0% | 0.37 | F | 0% | 0.98 | F |
| −1661A>G (rs4553808) | |||||||||||||||
| Overall | 27% | 0.24 | F | 9% | 0.35 | F | 14% | 0.32 | F | 6% | 0.37 | F | 24% | 0.26 | F |
| Chinese | 0% | 0.48 | F | 0% | 0.99 | F | 32% | 0.22 | F | 0% | 0.98 | F | 24% | 0.27 | F |
| PB | 39% | 0.18 | F | 31% | 0.23 | F | 27% | 0.25 | F | 30% | 0.24 | F | 34% | 0.21 | F |
| HWE | 0% | 0.48 | F | 0% | 0.99 | F | 32% | 0.22 | F | 0% | 0.98 | F | 24% | 0.27 | F |
Notes.
- EM
- Effects model
- F
- fixed effects model
- R
- random effects model
- PB
- population based
- HB
- hospital based
- SNP
- single-nucleotide polymorphism
- HWE
- subgroup excluding the study departing from HWE