Table 2.
Clinical and infectious characteristics of all patients with an ICU LOS of more than24 hours
| Characteristic | Center 1 | Center 2 | Center 3 | Center 4 | Center 5 | Total |
| Enrolled patients (n) | 359 | 146 | 125 | 76 | 178 | 884 |
| Median age (IQR) | 73.6 (58.5–81.5) | 55.4 (42.5–60.6) | 47.6 (32.0–66.9) | 61.4 (44.2–68.7) | 68.9 (57.8–77.1) | 66.4 (49.2–77.1) |
| Male/female (%) | 62/38 | 59/41 | 59/41 | 62/38 | 51/49 | 59/41 |
| Median APACHE II score (IQR) | 16 (11–21) | 17.5 (9.7–25.2) | 16 (12–20) | 16 (10–20) | 18 (14–21) | 17 (11–22) |
| First-day SOFA score (IQR) | 3 (1–5) | 6 (2.7–9) | 6 (3–8) | 4 (2–7) | 6 (4–9) | 4 (2–8) |
| Median ICU LOS, days (IQR) | 3 (2–7) | 5.5 (3–10.2) | 6 (3–12) | 3 (2–7.7) | 4 (2–10) | 4 (2–9) |
| Main ICU admission diagnosis | ||||||
| Respiratory infection, n (%) | 43 (11.9) | 16 (10.9) | 10 (8.0) | 12 (15.8) | 42 (23.6) | 123 (13.9) |
| Acute coronary syndrome, n (%) | 52 (14.5) | 24 (16.4) | 4 (3.2) | 25 (32.9) | 2 (1.1) | 107 (12.0) |
| GI postoperative patients, n (%) | 9 (2.5) | 11 (7.5) | 5 (4.0) | 7 (9.2) | 50 (28.1) | 82 (9.3) |
| Sepsis, n (%) | 34 (9.5) | 2 (1.4) | 17 (13.6) | 3 (3.9) | 13 (7.3) | 69 (7.8) |
| GI surgery for neoplasm, n (%) | 22 (6.1) | 4 (2.7) | 4 (3.2) | 7 (9.2) | 25 (14.0) | 62 (7.0) |
| Cardiovascular surgery, n (%) | 38 (10.6) | 1 (0.06) | 4 (3.2) | - | 18 (10.1) | 61 (6.9) |
| Clinical neurological disorders, n (%) | 36 (10.0) | 10 (6.8) | 6 (4.8) | - | 5 (02.8) | 57 (6.4) |
| Site of infection | ||||||
| Lung, n (%) | 86 (72.3) | 30 (43.5) | 52 (67.5) | 24 (68.5) | 75 (70.1) | 267 (65.6) |
| Urinary tract, n (%) | 9 (7.6) | 4 (5.7) | 5 (6.5) | - | 5 (4.7) | 23 (5.6) |
| Abdomen/surgical wound, n (%) | 4 (3.3) | 5 (7.3) | - | 5 (14.3) | 6 (5.6) | 20 (4.9) |
| Bloodstream, n (%) | 5 (4.2) | 1 (1.5) | 1 (1.3) | 3 (8.6) | 21 (19.6) | 10 (2.5) |
| Other/unknown, n (%) | 15 (12.6) | 29 (42.2) | 19 (24.7) | 3 (8.6) | 21 (19.6) | 87 (21.4) |
| Diagnosed infections, n (%) | 119 (100) | 69 (100) | 77 (100) | 35 (100) | 107 (100) | 407 (100) |
| Enrolled patients, n | ||||||
| Consensus Conference Diagnosis | 359 | 146 | 125 | 76 | 178 | 884 (100%) |
| SIRS | 291 | 130 | 122 | 74 | 168 | 785 (88.8%) |
| Sepsis | 121 | 72 | 79 | 34 | 109 | 415 (46.9%) |
| Severe sepsis | 57 | 38 | 46 | 191 | 81 | 241 (27.3%) |
| Septic shock | 42 | 34 | 39 | 16 | 72 | 203 (23.0%) |
| Overall mortality rate (%) | 12.5 | 32.2 | 23.7 | 24.8 | 31.4 | 22.3 |
GI, gastrointestinal; IQR, interquartile range; LOS, length of stay; SIRS, systemic inflammatory response syndrome; SOFA, sequential organ failure assessment.