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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Cancer Res. 2016 Sep 26;76(23):6964–6974. doi: 10.1158/0008-5472.CAN-16-0258

Figure 4. Tumor PD-L1 regulates response to pharmacologic autophagy inhibitors.

Figure 4

A. Indicated cells were cultured with 50 μM chloroquine and proliferation inhibition (100%-% proliferation by MTT, with control set at 0%) assessed 72 h later. P values from unpaired t test. B-D, wild type mice challenged with indicated cells and treated with chloroquine (CQ) or 3-methyladenine (3MA) as described in Materials and Methods. p-values, two-way ANOVA. PBS, phosphate buffered saline control. E-F. βδ TCR KO mice challenged and treated as in B-D. G-H. NSG mice challenged and treated as in B-D. I. Indicated B16 cells from basal (+) or serum starved (−) (24 h) conditions and cell viability normalized to basal controls assessed on a Vi-Cell. P values from unpaired t test. J. WT females challenged with indicated ID8agg, 4 x 106 cells intraperitoneally, and treated with chloroquine or 3MA as in panels B-D. No differences are significant.