Figure 3.

Cisplatin promotes migratory and invasive capacity in osteosarcoma. (A) Migratory capacity was analyzed by wound healing assay and (B) invasive capacity was analyzed by Transwell assay. The cisplatin treated cells exhibited significantly increased cell migration and invasion compared with the control cells. *P<0.05. (C) Transplantation assay in mice revealed that cisplatin exposure promoted pulmonary metastasis and lung destruction, although the primary tumor was inhibited (magnification, ×100; Scale, 100 µm).