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Expression of miR-497 in osteosarcoma. Relative expression levels of miR-497 in (A) osteosarcoma and adjacent tissues; (B) the serum of healthy subjects and patients with osteosarcoma; and (C) lung metastatic and adjacent tissues. Reverse transcription-quantitative polymerase chain reaction was performed to determine mRNA expression levels. Histogram data are expressed as the mean ± standard deviation. *P<0.05, **P<0.01 vs. control group. miRNA/miR, microRNA.
