Table 2.
PLA Antibacterial Activity against Clinical Isolates (MICs in μg/mL)
| Inhibitor | UCH MRSA 1 (dfrG) | UCH MRSA 115 (dfrA) | UCH MRSA 121 (dfrG) | UCH MRSA 127 (dfrG) | HH MRSA 714 (dfrG) | HH MRSA 1144 (dfrA) | HH MRSA 1184 (dfrK) | UCH MSSA 1 (dfrG) | ATCC 43300 |
|---|---|---|---|---|---|---|---|---|---|
| UCP1039 | 1.25 | >20 | 0.625 | 0.3125 | 1.25 | >10 | 1.25 | 0.625 | 0.0391 |
| UCP1164 | 2.5 | 10 | 5 | 2.5 | 5 | 5 | 0.625 | 5 | 0.0391 |
| UCP1172 | 0.625 | 5 | 0.625 | 0.3125 | 0.625 | 5 | 0.3125 | 0.3125 | 0.0098 |
| UCP1173 | 5 | 2.5 | 5 | 2.5 | 5 | 1.25 | 2.5 | 2.5 | 0.0098 |
| UCP1175 | 2.5 | >20 | 10 | 5 | 10 | >20 | 5 | 10 | 0.0195 |
| UCP1191 | 0.625 | 20 | 0.625 | 0.1563 | 0.625 | 10 | 0.1563 | 0.3125 | 0.0195 |
| UCP1205 | 0.625 | >10 | 0.625 | 0.3125 | 0.625 | >10 | 0.3125 | 0.3125 | 0.0195 |
| UCP1206 | 2.5 | >10 | 2.5 | 1.25 | 2.5 | >10 | 1.25 | 1.25 | 0.0098 |
| UCP1191 +SMXa | 0.0391 | 00.625 | 0.0781 | 0.3125 | 0.0391 | 0.625 | ≤ 0.0098 | 0.0098 | ≤ 0.0048 |
a
MIC values with 100 μg/mL Sulfamethoxazole (SMX), ATCC 43300 and UCH 127 at 1 μg/mL SMX