Table 3.

Enzyme Inhibition (IC₅₀ values shown in μM)

Inhibitor	DfrB (wt SaDHFR)	DfrG	DfrA	DfrK
TMP	0.023 ± 0.002	380 ± 12	15.1 ± 0.7	43 ± 2
UCP1039	0.014 ± 0.001	0.45 ± 0.02	0.36 ± 0.02	0.022 ± 0.003
UCP1164	0.037 ± 0.002	1.4 ± 0.1	8.8 ± 0.9	0.073 ± 0.002
UCP1172	0.0089 ± 0.0007	0.22 ± 0.02	0.41 ± 0.01	0.030 ± 0.001
UCP1173	0.014 ± 0.001	0.19 ± 0.01	0.27 ± 0.02	0.091 ± 0.008
UCP1175	0.0110 ± 0.0006	1.4 ± 0.2	0.98 ± 0.008	0.17 ± 0.01
UCP1191	0.010 ± 0.0002	0.087 ± 0.005	0.32 ± 0.03	0.041 ± 0.006
UCP1205	0.018 ± 0.003	0.159 ± 0.007	0.34 ± 0.01	0.10 ± 0.01
UCP1206	0.017 ± 0.002	0.19 ± 0.01	0.18 ± 0.03	0.054 ± 0.005