Table 3.
Mean daily dose and mean plasma level of lamotrigine for different patient characteristics.
| Characteristic | Lamotrigine dose (mg) |
Lamotrigine concentration (mg/l) |
||||
|---|---|---|---|---|---|---|
| Mean (SD) | t test (df) | p value | Mean (SD) | t test (df) | p value | |
| Gender | ||||||
| Female | 225.39 (156.47) | −0.078 (185) | 0.938 | 5.93 (3.34) | 0.151 (115) | 0.093 |
| Male | 227.31 (164.69) | 5.84 (2.62) | ||||
| Ethnicity | ||||||
| Black and Asian | 210.49 (167.43) | −0.596 (185) | 0.552 | 6.83 (2.64) | 1.28 (185) | 0.552 |
| White | 229.15 (157.58) | 5.76 (3.17) | ||||
| Enzyme inducer | ||||||
| Yes | 270.00 (249.39) | 0.583 (9.386)* | 0.574 | 3.40 (1.54) | −2.047 (115) | 0.043 |
| No | 223.57 (152.97) | 6.03 (3.13) | ||||
| Enzyme inhibitor | ||||||
| Yes | 200.93 (138.59) | −0.888 (185) | 0.376 | 7.47 (3.99) | 2.218 (27.337)* | 0.035 |
| No | 230.30 (162.13) | 5.52 (2.75) | ||||
| Smoking status | ||||||
| Yes | 240.51 (170.58) | 1.692 (146) | 0.093 | 5.88 (2.91) | 0.282 (89) | 0.779 |
| No | 192.86 (140.22) | 5.70 (3.01) | ||||
| Diagnosis | ||||||
| Scz/SA | 250.27 (172.41) | 0.746 (2,184)# | 0.476 | 5.95 (2.59) | 2.641 (2,114)# | 0.076 |
| BAD | 212.72 (145.95) | 6.86 (3.97) | ||||
| Other | 226.06 (158.60) | 5.27 (2.71) | ||||
| Reasons for lamotrigine | ||||||
| BAD/TRD | 231.92 (160.18) | 3.708 (2,184)# | 0.026 | 6.57 (3.78) | 1.381 (2,114) | 0.256 |
| Clozapine augmentation | 280.00 (182.68) | 5.75 (2.46) | ||||
| Other | 200.13 (142.41) | 5.47 (2.87) | ||||
Significant results are in bold (p < 0.05).
*
Welch’s t test; #Analysis of variance (ANOVA) F test.
BAD, bipolar affective disorder; df, degrees of freedom; SA, schizoaffective disorder; Scz, schizophrenia; TRD, treatment-resistant depression.