Table 3.
Univariate association between prognostic factors and best response within 180 days post-transplant
| Covariate | Level | n | Odds of having sCR or CR
|
||||
|---|---|---|---|---|---|---|---|
| OR | 95% CI | OR P-value |
Overall P-value |
||||
| Age (years) | 65+ | 36 | 0.55 | 0.21 | 1.41 | 0.21 | 0.21 |
| <65 | 62 | Ref | – | – | – | ||
| Cytogenetics | High risk | 24 | 1.73 | 0.52 | 5.70 | 0.37 | 0.37 |
| Standard Risk | 74 | Ref | – | – | – | ||
| Previous transplant | No | 78 | 2.80 | 0.97 | 8.06 | 0.06 | 0.06 |
| Yes | 20 | Ref | – | – | – | ||
| Early or salvage | Early | 63 | 2.47 | 0.95 | 6.40 | 0.06 | 0.06 |
| Salvage | 35 | Ref | – | – | – | ||
| Durie-Salmon staging and subclassification at diagnosis | II | 12 | 0.51 | 0.10 | 2.57 | 0.41 | 0.22 |
| III | 69 | 1.57 | 0.43 | 5.71 | 0.50 | ||
| I | 15 | Ref | – | – | – | ||
| ISS | II | 32 | 0.71 | 0.20 | 2.56 | 0.61 | 0.65 |
| III | 26 | 0.54 | 0.15 | 1.98 | 0.35 | ||
| I | 30 | Ref | – | – | – | ||
| R-ISS | II | 40 | 0.18 | 0.02 | 1.50 | 0.11 | 0.19 |
| III | 11 | 0.59 | 0.03 | 10.48 | 0.72 | ||
| I | 18 | Ref | – | – | – | ||
| Tandem or single | Tandem | 51 | 1.98 | 0.76 | 5.14 | 0.16 | 0.16 |
| Single | 47 | Ref | – | – | – | ||
| Creatinine at diagnosis | Units =1 | 90 | 0.94 | 0.82 | 1.09 | 0.40 | 0.40 |
| Albumin at diagnosis | Units =1 | 90 | 1.21 | 0.66 | 2.22 | 0.54 | 0.54 |
| LDH at diagnosis | Units =1 | 64 | 2.48 | 0.57 | 10.89 | 0.23 | 0.23 |
Abbreviations: CI, confidence interval; LDH, lactate dehydrogenase; OR, odds ratio; ISS, International Staging System; CR, complete response; R-ISS, revised International Staging System; sCR, stringent complete response; Ref, reference.