Table 4.
Univariate association between prognostic factors and MRD status within 180-days post-transplant
| Covariate | Level | n | Odds of MRD positivity
|
||||
|---|---|---|---|---|---|---|---|
| OR | 95% CI | OR P-value |
Overall P-value |
||||
| Age (years) | 65+ | 36 | 1.83 | 0.58 | 5.72 | 0.30 | 0.30 |
| <65 | 60 | Ref | – | – | – | ||
| Cytogenetics | High risk | 24 | 0.79 | 0.20 | 3.12 | 0.74 | 0.74 |
| Standard risk | 72 | Ref | – | – | – | ||
| Previous transplant | No | 77 | 0.56 | 0.15 | 2.03 | 0.38 | 0.38 |
| Yes | 19 | Ref | – | – | – | ||
| Early or salvage | Early | 62 | 0.35 | 0.11 | 1.11 | 0.07 | 0.07 |
| Salvage | 34 | Ref | – | – | – | ||
| Durie-Salmon staging and subclassification at diagnosis | II | 11 | 0.61 | 0.09 | 4.14 | 0.61 | 0.25 |
| III | 68 | 0.32 | 0.08 | 1.26 | 0.10 | ||
| I | 15 | Ref | – | – | – | ||
| ISS | II | 31 | 0.13 | 0.01 | 1.14 | 0.07 | 0.17 |
| III | 26 | 0.91 | 0.24 | 3.44 | 0.89 | ||
| I | 29 | Ref | – | – | – | ||
| R-ISS | II | 39 | 2.91 | 0.32 | 26.24 | 0.34 | 0.59 |
| III | 11 | 1.60 | 0.09 | 28.56 | 0.75 | ||
| I | 17 | Ref | – | – | – | ||
| Tandem or single | Tandem | 51 | 0.86 | 0.28 | 2.68 | 0.80 | 0.80 |
| Single | 45 | Ref | – | – | – | ||
| Creatinine at diagnosis | Units =1 | 88 | 0.94 | 0.72 | 1.23 | 0.67 | 0.67 |
| Albumin at diagnosis | Units =1 | 88 | 0.75 | 0.36 | 1.53 | 0.42 | 0.42 |
| LDH at diagnosis | Units =1 | 62 | 0.41 | 0.05 | 3.14 | 0.39 | 0.39 |
Abbreviations: CI, confidence interval; LDH, lactate dehydrogenase; MRD, minimal residual disease; OR, odds ratio; ISS, International Staging System; R-ISS, revised International Staging System; Ref, reference.