TABLE 2.
Survival analysis of time to clinical malariaa
| Antigen | Regression coefficient (B) | Hazard ratio | 95% CI | P value |
|---|---|---|---|---|
| K1 Block 2 type | ||||
| 3D7 Block 2 | −1.035 | 0.355 | (0.117-1.075) | 0.067 |
| 3D7 repeats | −0.448 | 0.639 | (0.246-1.659) | 0.358 |
| Palo Alto Block 2 | −1.223 | 0.294 | (0.088-0.982) | 0.047* |
| Palo Alto repeats | −0.939 | 0.391 | (0.055-2.801) | 0.350 |
| DWK1#1 Block 2 | −1.060 | 0.347 | (0.121-0.989) | 0.048* |
| DWK1#2 Block 2 | −1.580 | 0.206 | (0.033-1.284) | 0.091 |
| K1 flanking | −0.844 | 0.430 | (0.091-2.031) | 0.287 |
| MAD20 Block 2 type | ||||
| MAD20 Block 2 | −1.847 | 0.158 | (0.032-0.779) | 0.023* |
| MAD20 repeats | −0.858 | 0.424 | (0.091-1.985) | 0.276 |
| Wellcome Block 2 | −2.209 | 0.110 | (0.014-0.878) | 0.037* |
| Wellcome repeats | −1.210 | 0.298 | (0.047-1.873) | 0.197 |
| DWMAD20 Block 2 | −1.364 | 0.256 | (0.064-1.023) | 0.054 |
| MAD20 type flanking | −1.770 | 0.170 | (0.010-2.927) | 0.223 |
| RO33 Block 2 type | ||||
| RO33 Block 2 | −0.432 | 0.649 | (0.184-2.283) | 0.500 |
| DWRO33 Block 2 | −0.153 | 0.858 | (0.284-2.590) | 0.786 |
| Any Block 2 | −0.453 | 0.636 | (0.351-1.152) | 0.135 |
| Block 1 | −0.419 | 0.658 | (0.107-4.047) | 0.651 |
| MSP-119 | 0.049 | 1.050 | (0.809-1.362) | 0.715 |
a
Survival analysis calculated by using Cox proportional hazards model of the times to clinical malaria episodes in the cohort, for each antigen tested. Age was included in each model as a confounding variable as follows: coefficient (B), −0.703; hazard ratio, 0.495; 95% confidence interval (CI), (0.354-0.693); P value, < 0.0001***.