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Treatment of infected IL-4/IL-10 KO mice with anti-IFN-γ antibodies (horizontal stripes) has no effect on worm load compared to that in IL-4/IL-10 mice treated with control Ig. C57BL/6, IL-10 KO, IL-4 KO, and IL-4/IL-10 KO mice were naturally infected with L. sigmodontis, and the worm load was analyzed 65 days later. *, significant increase in IL-4 KO mice compared to all other genotypes of mice (P < 0.05), with four to seven mice per group (four in the antibody-treated groups).
