FIG. 1.

Estimated generation times for C. burnetii in J774 cells and primary murine macrophages. Generation times were calculated by the formula G = t/[3.3 × log(b/B)], where G is the generation time, t is the time interval, in hours, b is the number of bacteria at the end of the time interval, and B is the number of bacteria at the beginning of the time interval. (A) Replication rates in J774.16 cells. J774.16, 45 h; J774D.9, 20 h. (B) Replication rates in peritoneal macrophages. Wild-type PMφ, 26 h; p47^phox−/− PMφ, 19 h; iNOS^−/− PMφ, 17 h. C. burnetii replication rates in cells lacking either iNOS or NADPH oxidase were significantly (P < 0.05) faster than replication rates in wild-type cells.