TABLE 1.
Severity of histopathologic changes in selected tissues of mice infected with C. burnetii
| Tissue or mouse strain | Histopathology scorea with indicated dose of C. burnetii
|
|||
|---|---|---|---|---|
| 104
|
107
|
|||
| 14 dpi | 28 dpi | 14 dpi | 28 dpi | |
| Lung | ||||
| Wild type | 2 | 0 | 3 | 1 |
| iNOS KO | 3 | 1 | 4 | 1 |
| phox KO | 4 | 2 | 5 | 3 |
| Liver | ||||
| Wild type | 3 | 2 | 4 | 3 |
| iNOS KO | 2 | 1 | 4 | 3 |
| phox KO | 2 | 3 | 5 | 4 |
| Spleen | ||||
| Wild type | 3 | 2 | 5 | 4 |
| iNOS KO | 3 | 3 | 5 | 4 |
| phox KO | 5 | 5 | 5 | 5 |
a
Severity was based on the amount of architectural change, cellular infiltration, and the presence or absence of necrosis: 0, none; 1, mild; 2, mild to moderate; 3, moderate; 4, moderate to severe; 5, severe. One section from three mice per group was evaluated. The evaluation of tissue sections was done in a blinded fashion.